Piericidin a

Catalog Number

ACM2738649

Product Name

Piericidin a

Structure

CAS

2738-64-9

Category

Inhibitors

Description

Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity.

Synonyms

PIERICIDIN A;

IUPAC Name

2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one

Molecular Weight

415.57

Molecular Formula

C₂₅H₃₇NO₄

Canonical SMILES

COC1=C(C(C)=C(N=C1OC)C/C=C(C/C=C/C(C)=C/[C@@H](C)[C@H](/C(C)=C/C)O)\C)O

InChI Key

BBLGCDSLCDDALX-LKGBESRRSA-N

Boiling Point

591.7ºC at 760 mmHg. 产品描述 安全性:

Flash Point

85ºC

Density

1.05 g/cm³

Appearance

Liquid

Storage

Solution, -20°C, 2 years

Exact Mass

415.27200

Hazard Statements

T+

H-Bond Acceptor

5

H-Bond Donor

2

Shipping

Can be shipped at room temperature, where not in use may vary.

Source

Streptomyces sp. BCC24731

MSDS

COA

Spec Sheet