Fmoc-His(Clt)-OH

CAS
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CAS
224032-19-3
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Catalog Number

ACM224032193-1

Product Name

Fmoc-His(Clt)-OH

Structure

CAS

224032-19-3

Category

Amino Acids

Description

A useful derivative for the convergent synthesis of peptide due to the enhanced stability of Clt group compared to Trt group to mildy acidic reagents. Fmoc-His-(Clt)-OH gives approximately a third less racemization when compared to Fmoc-His(Trt)-OH during slow coupling reactions.

Synonyms

Fmoc-His(Clt)-OH, N-α-Fmoc-N-im-2-chlorotrityl-L-histidine

Molecular Weight

654.15

InChI

1S/C40H32ClN3O4/c41-36-22-12-11-21-35(36)40(27-13-3-1-4-14-27,28-15-5-2-6-16-28)44-24-29(42-26-44)23-37(38(45)46)43-39(47)48-25-34-32-19-9-7-17-30(32)31-18-8-10-20-33(31)34/h1-22,24,26,34,37H,23,25H2,(H,43,47)(H,45,46)/t37-/m0/s1

InChI Key

SYGADBVEKBWUKO-QNGWXLTQSA-N

Application

Peptide synthesis.

Form

powder

Functional Group

Fmoc

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Storage Temperature

15-25℃