Catalog Number
ACM134379774
Product Name
Dexelvucitabine
Description
Dexelvucitabine, also known as DPC-817; INCB-8721; PSI-5582; YZ-817, DOC-817, is a nucleoside reverse transcriptase inhibitor potentially for the treatment of HIV infection.
Synonyms
Dexelvucitabine; beta-D-D-4FC; D-D-4FC; DFC; DPC-817; RVT; INCB-8721; PSI-5582; YZ-817; DOC-817
IUPAC Name
4-amino-5-fluoro-1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)pyrimidin-2(1H)-one
Molecular Formula
C9H10FN3O3
Canonical SMILES
OC[C@@H]1C=C[C@H](N2C(N=C(C(F)=C2)N)=O)O1
InChI
InChI=1S/C9H10FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h1-3,5,7,14H,4H2,(H2,11,12,15)/t5-,7+/m0/s1
InChI Key
HSBKFSPNDWWPSL-CAHLUQPWSA-N
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Storage
Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Biological Target
Dexelvucitabine (Reverset), a cytidine analog, is a nucleoside reverse transcriptase inhibitor against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2'-deoxycytidine antiretroviral agent.
Drug Formulation
This drug may be formulated in DMSO
Elemental Analysis
C, 47.58; H, 4.44; F, 8.36; N, 18.50; O, 21.13
HS Tariff Code
2934.99.9001
Shipping
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Stock Solution Storage
0-4 °C for short term (days to weeks), or -20 °C for long term (months).
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