Fmoc-D-Dpr(ivDde)-OH

Catalog Number

ACM1228900159-1

Product Name

Fmoc-D-Dpr(ivDde)-OH

Structure

CAS

1228900-15-9

Category

Amino Acids

Description

This orthogonally-protected derivative is based on the hindered Dde variant ivDde. It has very similar chemical properties to Fmoc-Lys(Dde)-OH, except that the side-chain ivDde group is considerably more stable to piperidine than Dde, and is less prone to migrate from protected to unprotected lysine side-chains. When removing ivDde in the presence of allyl based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group. Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Synonyms

Fmoc-D-Dpr(ivDde)-OH, N-α-Fmoc-N-β-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-D-diaminopropionic acid

Molecular Weight

532.63

Application

Peptide synthesis.

Assay

≥90.0% (acidimetric)
≥95.0% (HPLC)
≥98% (TLC)

Form

powder

Functional Group

amine

Quality Level

200

Reaction Suitability

reaction type: Fmoc solid-phase peptide synthesis

Storage Temperature

15-25℃

MSDS

COA

Spec Sheet