Tang X1, Han Y, Ma S.
Org Lett. 2015 Mar 6;17(5):1176-9. doi: 10.1021/acs.orglett.5b00105. Epub 2015 Feb 12.A cadmium iodide mediated tandem reaction involving amine and two molecules of terminal alkynes for the synthesis of trisubstituted allenes has been developed. By applying this protocol, methyl-substituted allenes may be obtained easily from two molecules of terminal alkynes and pyrrolidine via methyl ketoniminium and propargylic amine formation, 1,5-hydride transfer and β-elimination.