Eey ST1, Lear MJ.
Chemistry. 2014 Sep 1;20(36):11556-73. doi: 10.1002/chem.201400131. Epub 2014 Jul 22.(-)-Platensimycin is a potent inhibitor of fatty acid synthase that holds promise in the treatment of metabolic disorders (e.g., diabetes and "fatty liver") and pathogenic infections (e.g., those caused by drug-resistant bacteria). Herein, we describe its total synthesis through a four-step preparation of the aromatic amine fragment and an improved stereocontrolled assembly of the ketolide fragment, (-)-platensic acid. Read More