Baradzenka AG1, Barysau BM1, Hurski AL1, Zhabinskii VN2, Khripach VA1.
Steroids. 2015 Sep;101:90-5. doi: 10.1016/j.steroids.2015.06.004. Epub 2015 Jun 13.The aim of this work was to prepare 24-epicryptolide and 22-dehydro-24-epibrassinolide as possible metabolites of 24-epibrassinolide. The main synthetic problem to be solved was the differentiation of functional groups in brassinosteroids. Distinguishing 2α,3α-diol function from another diol group in 24-epibrassinolide was achieved via selective hydrolysis of 2α,3α-cyclic carbonate or via regioselective reaction of boric acid with the functional groups in the side chain. Read More