Dago CD1,2, Ambeu CN3,4, Coulibaly WK5, Békro YA6, Mamyrbékova J7, Defontaine A8, Baratte B9, Bach S10, Ruchaud S11, Guével RL12, Ravache M13, Corlu A14, Bazureau JP15.
Molecules. 2015 Jul 8;20(7):12412-35. doi: 10.3390/molecules200712412.A new route to 3-(4-arylmethylamino)butyl-5-arylidene-2-thioxo-1,3-thiazolidine-4-one 9 was developed in six steps from commercial 1,4-diaminobutane 1 as starting material. The key step of this multi-step synthesis involved a solution phase "one-pot two-steps" approach assisted by microwave dielectric from N-(arylmethyl)butane-1,4-diamine hydrochloride 6a-f (as source of the first point diversity) and commercial bis-(carboxymethyl)-trithiocarbonate reagent 7 for construction of the rhodanine platform. Read More