Kolšek K1, Gobec M1, Mlinarič Raščan I1, Sollner Dolenc M2.
Toxicol In Vitro. 2015 Feb;29(1):8-15. doi: 10.1016/j.tiv.2014.08.009. Epub 2014 Sep 2.A homeostasis of the glucocorticoid and androgen endocrine system is essential to human health. Their disturbance can lead to various diseases, for example cardiovascular, inflammatory and autoimmune diseases, infertility, cancer. Fifteen widely used industrial chemicals that disrupt endocrine activity were selected for evaluation of potential (anti)glucocorticoid and (anti)androgenic activities. The human breast carcinoma MDA-kb2 cell line was utilized for reporter gene assays, since it expresses both the androgen and the glucocorticoid-responsive reporter. Read More