Tian M1, Qing C1, Niu Y1, Dong J1, Cao X1, Song F1, Ji X1, Lu S1.
Arch Med Sci. 2016 Feb 1;12(1):179-87. doi: 10.5114/aoms.2016.57595. Epub 2016 Feb 2.INTRODUCTION: The aim of the study was to explore the effect of aminoguanidine cream on the skin tissue microenvironment in diabetic rats.MATERIAL AND METHODS: A total of 51 healthy male Sprague Dawley (SD) rats were randomly divided into three groups: the diabetes group (n = 18), the aminoguanidine group (n = 18) and the control group (n = 15). Rats in the diabetes group and aminoguanidine group were injected with 65 mg/kg streptozotocin to induce the diabetes model, and in the control group with citrate buffer. Read More