Wise SS1, Holmes AL, Qin Q, Xie H, Katsifis SP, Thompson WD, Wise JP Sr.
Chem Res Toxicol. 2010 Feb 15;23(2):365-72. doi: 10.1021/tx900363j.Hexavalent chromium (Cr(VI)) compounds are well-established human lung carcinogens. Solubility plays an important role in their carcinogenicity with the particulate Cr(VI) compounds being the most carcinogenic. Epidemiology and animal studies suggest that zinc chromate is the most potent particulate Cr(VI) compound; however, there are few comparative data to support these observations. The purpose of this study was to compare the genotoxicity of zinc chromate with two other particulate Cr(VI) compounds, barium chromate and lead chromate, and one soluble Cr(VI) compound, sodium chromate. Read More