Sung U1, Binda F2, Savchenko V3, Owens WA4, Daws LC5.
J Chem Neuroanat. 2016 Dec 22. pii: S0891-0618(16)30096-5. doi: 10.1016/j.jchemneu.2016.12.003. [Epub ahead of print]The antidepressant-sensitive norepinephrine (NE) transporter (NET) inactivates NE released during central and peripheral neuronal activity by transport into presynaptic cells. Altered NE clearance due to dysfunction of NET has been associated with the development of mental illness and cardiovascular diseases. NET activity in vivo is influenced by stress, neuronal activity, hormones and drugs. We investigated the mechanisms of Ca2+ regulation of NET and found that Ca2+ influenced both Vmax and Km for NE transport into cortical synaptosomes. Read More