Ceramides as Novel Disease Biomarkers

Original Article:
Ceramides as Novel Disease Biomarkers

Jennifer Kurz, et al.

Trends in molecular medicine, 2019, 25 (1), 20-32.

10.1016/j.molmed.2018.10.009

This article reviews the regulatory role of ceramides in a range of different diseases and their potential use as biomarkers in diagnosis, disease staging, and personalized medicine. This work summarizes published studies on ceramide regulation in different diseases, reflecting the potential for biomarker applications. The scheme shows measurable body fluids that might be used to detect ceramide up/downregulation in different pathological conditions.

Disease areas where ceramides are used as biomarkers include:

> Lipid Disorders: Farber Disease (FD);

> Cancer: Ovarian Cancer, Colorectal Cancer (CRC);

> Autoimmune Diseases: Osteoarthritis (OA)/Rheumatoid Arthritis (RA), Multiple Sclerosis (MS);

> Metabolic Disease: Type 2 Diabetes Mellitus (T2D);

> Neurological Diseases: Alzheimer's disease (AD);

> Depression

> Cardiovascular Diseases: Coronary artery disease (CAD).