Original Article:
Hydroxyapatite for Biomedical Applications: A Short Overview
Elisa Fiume, et al.
Ceramics, 2021, 4(4), 542-563.
10.3390/ceramics4040039
Hydroxyapatite (HA) plays an important role in the development of bone tissue engineering (BTE) products. HA is biocompatible, highly osteoconductive, and more chemically stable than tricalcium phosphate (TCP) in contact with body fluids. This review introduces the chemical structure and properties of HA, the synthesis technology of HA, and the application of HA in tissue engineering.
> Chemical structure and properties of HA
As shown in the figure, HA exhibits a rather complex crystalline structure consisting of phosphate ions (PO43-), hydroxyl ions (OH-) and calcium ions (Ca2+), and there are two formula units in the cell of the crystallographic unit. In addition, the shape, size, and distribution of HA crystals also significantly affect the mechanical, biochemical, and biological properties of the material.
> Synthesis technology of HA
The main processing technologies of HA include Solid-state synthesis, Mechanochemical method, Hydrothermal method, Sol-gel method, Sonochemical method, and Synthesis method based on biological sources.
> Applications of HA in BTE
Past studies have shown that HA is able to create a favorable environment that promotes ingrowth and regeneration of new bone tissue, allowing perfect integration of the graft without causing the development of a severe immune response. Major biomedical applications of HA include bone defect filling (e.g., augmentation and stabilization of the jaw in maxillofacial reconstruction), spinal fusion, bone filling after tumor surgery, middle ear bone replacement, and orbital floor fracture repair. Moreover, great results were also achieved in the development of drug delivery systems and carriers of bioactive peptides and/or various cell types.
Chemicals Related in the Paper:
| Catalog Number | Product Name | Structure | CAS Number | Price |
|---|---|---|---|---|
| ACM1306065 | Hydroxyapatite Nanoparticles / Nanopowder |  |
1306-06-5 | Price |
