Lovchik MA1, Kraft P2.
Chemistry. 2016 Dec 23. doi: 10.1002/chem.201605378. [Epub ahead of print]The silicon analogue of the potent spirocyclic δ-damascone odorant 6 was synthesized from allyltrichlorosilane (15) and but-2-en-1-ol (16). The latter was transformed to 3-methylpen-4-enenitrile (11) by Saucy-Marbet reaction with ethoxyethane and subsequent treatment with HONH2·HCl. The resulting γ,δ-unsaturated nitrile 11 was silylated with 1-allyl-1-chlorosilolane (14), which was prepared from allyltrichlorosilane (15) and the bis-Grignard reagent of 1,4-dichlorobutane. Read More