Westermaier T1, Nickl R1, Koehler S1, Fricke P1, Stetter C1, Rueckriegel SM1, Ernestus RI1.
J Neurol Surg A Cent Eur Neurosurg. 2016 Dec 30. doi: 10.1055/s-0036-1596057. [Epub ahead of print]Background In experimental models of neuronal damage, therapeutic hypothermia proved to be a powerful neuroprotective method. In clinical studies of traumatic brain injury (TBI), this very distinct effect was not reproducible. Several meta-analyses draw different conclusions about whether therapeutic hypothermia can improve outcome after TBI. Adverse side effects of systemic hypothermia, such as severe pneumonia, have been held responsible by some authors to counteract the neuroprotective effect. Read More