Cai HL1, Deng Y1, Fang PF1, Cao S1, Hou ZY1, Wu YQ1, Chen XJ2, Yan M3, Zhang B4.
J Pharm Biomed Anal. 2016 Dec 15;135:67-74. doi: 10.1016/j.jpba.2016.12.007. [Epub ahead of print]A robust and highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of pericyazine in human plasma. The plasma sample was alkalized with sodium hydroxide solution and handled by liquid-liquid extraction with ethyl acetate after adding perphenazine as an internal standard (IS). The analytes were separated on an Ultimate™ AQ-C18 analytical column at 40°C, with a gradient elution consisting of A (aqueous phase: 5mM ammonium acetate buffer solution containing 0. Read More