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Home > Product > Organic Silicon Compounds > Other Organosilicon > Tetrakis(dimethylamino)silane

Tetrakis(dimethylamino)silane | CAS Number: 1624-01-7

Catalog Number
ACM1624017
Product Name
Tetrakis(dimethylamino)silane
Structure
CAS Number
1624-01-7
EC Number
216-611-2
IUPAC Name
N-methyl-N-[tris(dimethylamino)silyl]methanamine
Synonyms
Tetrakis-dimethylamino-silan; Octamethylsilatetramine; octamethylsilanetetramine; Tetrakis(dimethylamino)silane; Silanetetramine,octamethyl; EINECS 216-611-2; Silane 48-12 tetrakis;
Category
Organic amino silane
Molecular Weight
204.39
Exact Mass
204.17700
Molecular Formula
C8H24N4Si
Boiling Point
74ºC (19 torr)
Melting Point
15ºC(lit.)
Flash Point
75.3ºC
Density
0.88
Purity
95%+
Appearance
Transparent liquid
SMILES
CN(C)[Si](N(C)C)(N(C)C)N(C)C
InChIKey
SSCVMVQLICADPI-UHFFFAOYSA-N
Safty Description
26-36/37/39-43-45
Hazard Statements
C: Corrosive;
WGK Germany
3
Packing Group
II
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1Stereoselective and improved syntheses and anticancer testing of 3'-O-silatranylthymidines.

Black CA1, Ucci JW, Vorpagel JS, Mauck MC, Fenlon EE.

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3521-3.

A stereoselective synthesis of 3'-O-((R,R,R)-trimethylsilatranyl)thymidine (R,R,R-1) and synthesis of 3'-O-silatranylthymidine (5) via an improved silatranylation procedure using tetrakis(dimethylamino)silane are reported. Diastereomeric mixture 1 showed more activity than R,R,R-1 or 5 in a primary anticancer screen against breast, CNS, and lung cell lines; demonstrating the import of the configuration and presence, respectively, of the silatrane methyl groups for growth inhibition.

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Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA