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Home > Product > Heterocyclic Organic Compounds > 6-Bromopyridine-2-boronic acid pinacol ester

6-Bromopyridine-2-boronic acid pinacol ester | CAS Number: 651358-83-7

Catalog Number
ACM651358837
Product Name
6-Bromopyridine-2-boronic acid pinacol ester
Structure
CAS Number
651358-83-7
Synonyms
2-BROMO-6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;6-BROMOPYRIDINE-2-BORONIC ACID PINACOL ESTER;6-Bromopyridine-2-boronic...;2-Bromopyridine-6-boronic acid pinacol ester;2-broMo-6-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
Molecular Weight
283.96
Molecular Formula
C11H15BBrNO2
Purity
95%
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1Synthesis of C-4 Substituted Amido Nicotine Derivatives via Copper(I)- and (II)-Catalyzed Cross-Coupling Reactions.

Zhu J1, Enamorado MF1, Comins DL1.

J Org Chem. 2016 Nov 18;81(22):11529-11534. Epub 2016 Nov 1.

The syntheses of seven novel amido nicotine derivatives 12-18 from (S)-nicotine are presented. (S)-Nicotine and (S)-6-chloronicotine derivatives were cross-coupled with the corresponding amides 6-10 at the C-4 position of the pyridine ring via copper(I)-mediated reactions. Derivatives 16-18 were also obtained via copper(II)-mediated reactions from (S)-nicotine containing a C-4 boronic acid pinacol ester group. The optimization of reaction conditions for both routes provided a useful method for preparing C-4 amide-containing nicotine analogs.

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