Paz-Schmidt RA1, Bonrath W, Plattner DA.
Anal Chem. 2009 May 1;81(9):3665-8. doi: 10.1021/ac802754q.A new approach for real-time mass spectrometric analysis and identification of intermediates in confined, pressurized vessels is presented. The high-pressure reaction media is depressurized, mixed with a solvent, and fed directly to the atmospheric pressure electrospray ionization source of a tandem mass spectrometer. The method was applied to track product evolution for the dehydration of hydroxenin monoacetate, a commercially, important vitamin A precursor, and for the hydrogenation of 5-norbornene-2-carbonitrile with Pd/CaCO(3) as catalyst. Read More