Wang C, Cai J, Zhang M, Zhao X.
J Org Chem. 2016 Dec 21. doi: 10.1021/acs.joc.6b02624. [Epub ahead of print]A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with selectfluor in the presence of Ag(I) has been presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag(I) is crucial for this chemoselective fluorination process. The transformation 4,6-diphenyl 5-fluoro-2-aminopyrimidine into N-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methylbenzenesulfonamide was discussed; and the reaction mechanism was investigated as well.