Obata M1, Hirohara S2.
J Photochem Photobiol B. 2016 Sep;162:324-31. doi: 10.1016/j.jphotobiol.2016.07.006. Epub 2016 Jul 9.Porphyrin derivatives for photodynamic therapy are frequently modified with hydrophilic groups to improve their water solubility; however, such hydrophilic groups not only improve the solubility but also affect the photodynamic behavior of the compound. The suitable number and pattern of the hydrophilic substituents depend on the nature of the hydrophilic groups. In this article, we explore the optimum architecture for 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (TFPP) derivatives bearing 2-hydroxyethylthio substituents. Read More