Sheriff J1, Claiborne TE1, Tran PL2, Kothadia R1, George S1, Kato YP3, Pinchuk L3, Slepian MJ1,2,4, Bluestein D1.
ACS Appl Mater Interfaces. 2015 Oct 7;7(39):22058-66. doi: 10.1021/acsami.5b07254. Epub 2015 Sep 23.Over the years, several polymers have been developed for use in prosthetic heart valves as alternatives to xenografts. However, most of these materials are beset with a variety of issues, including low material strength, biodegradation, high dynamic creep, calcification, and poor hemocompatibility. We studied the mechanical, surface, and flow-mediated thrombogenic response of poly(styrene-coblock-4-vinylbenzocyclobutene)-polyisobutylene-poly(styrene-coblock-4-vinylbenzocylcobutene) (xSIBS), a thermoset version of the thermoplastic elastomeric polyolefin poly(styrene-block-isobutylene-block-styrene) (SIBS), which has been shown to be resistant to in vivo hydrolysis, oxidation, and enzymolysis. Read More