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Home > Product > Material & Chemicals > Biomaterials > (4-Methoxybenzyl)phosphonic acid

(4-Methoxybenzyl)phosphonic acid | CAS Number: 40299-61-4

Catalog Number
ACM40299614
Product Name
(4-Methoxybenzyl)phosphonic acid
Structure
CAS Number
40299-61-4
Synonyms
(4-METHOXYBENZYL)PHOSPHONIC ACID;(4-Methoxybenzyl)phosphonic acid, 98 %
Molecular Weight
202.14
Molecular Formula
C8H11O4P
Purity
98 %
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1Kinetics and mechanism of beta-lactamase inhibition by phosphonamidates: the quest for a proton.

Rahil J1, Pratt RF.

Biochemistry. 1993 Oct 12;32(40):10763-72.

Four phosphonamidates were synthesized as potential beta-lactamase inhibitors. Three were methanephosphonamidates [CH3PO2-NHR/Ar, where R/Ar = 4-methoxybenzyl (3a), phenyl (3b), and m-nitrophenyl (3c)], while the fourth, PhCH2OCONHCH2PO2-NHPh (2a), also contained a beta-lactamase active site-directed amido side chain. The pH-rate profiles for the hydrolyses of these compounds in the absence of enzyme demonstrated the necessity of nitrogen protonation in the transition state; the reactive neutral form was the zwitterion, IH. Read More

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Tel:1-201-478-8534
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