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4-Acryloylmorpholine | CAS Number: 5117-12-4

Catalog Number
ACM5117124
Product Name
4-Acryloylmorpholine
Structure
CAS Number
5117-12-4
Synonyms
ACRYLOYL MORPHOLINE;4-ACRYLOYLMORPHOLINE;N-ACRYLOYLMORPHOLINE;4-(1-oxo-2-propenyl)-Morpholine;N-Acrolylmorpholine;N-Acrylylmorpholine;4-Acryloylmorpholine,98+%;Morpholine, 4-(1-oxo-2-propenyl)-
Molecular Weight
141.17
Molecular Formula
C7H11NO2
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1Photo- and thermo-responsive multicompartment hydrogels for synergistic delivery of gemcitabine and doxorubicin.

Wang C1, Zhang G1, Liu G2, Hu J3, Liu S4.

J Control Release. 2016 Nov 16. pii: S0168-3659(16)31203-2. doi: 10.1016/j.jconrel.2016.11.007. [Epub ahead of print]

Hydrogels have found promising applications in drug delivery due to their biocompatibility, high drug loading capability, and tunable release profiles. However, hydrogel-based carriers are primarily employed for delivering hydrophilic payloads while hydrophobic drugs cannot be efficiently delivered due to the lack of hydrophobic domains within conventional hydrogel matrices. Herein, we report that thermo- and photo-responsive hydrogels could be constructed from amphiphilic triblock copolymers, poly(N-isopropylacrylamide)-b-poly(4-acryloylmorpholine)-b-poly(2-((((2-nitrobenzyl)oxy)carbonyl) amino)ethyl methacrylate) (PNIPAM-b-PNAM-b-PNBOC), and the resulting hydrogels could be further engineered a new carrier for both hydrophilic gemcitabine (GCT) and hydrophobic doxorubicin (DOX). Read More

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Tel:1-201-478-8534
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Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA