Skledar DG1, Schmidt J2, Fic A1, Klopčič I1, Trontelj J1, Dolenc MS1, Finel M3, Mašič LP4.
Chemosphere. 2016 Aug;157:152-9. doi: 10.1016/j.chemosphere.2016.05.027. Epub 2016 May 21.Bisphenol S (BPS; bis[4-hydroxyphenyl]sulfone) is commonly used as a replacement for bisphenol A in numerous consumer products. The main goal of this study was to examine the influence of different metabolic reactions that BPS undergoes on the endocrine activity. We demonstrate that hydroxylation of the aromatic ring of BPS, catalyzed mainly by the cytochrome P450 enzymes CYP3A4 and CYP2C9, is its major in-vitro phase I biotransformation. Read More