Kozuma Y1, Yamamoto T, Ishikawa E, Yoshida F, Akutsu H, Matsuda M, Nakai K, Tsuruta W, Takano S, Matsumura A, Ninomiya H.
Neurosurgery. 2016 Feb;78(2):274-84. doi: 10.1227/NEU.0000000000001058.BACKGROUND: Appropriate hemostasis is essential for clear visualization of the neural structures and cleavage planes. It is also essential for avoiding heat-induced injury, minimizing blood loss, and reducing operative time.OBJECTIVE: To determine the role of cerebrospinal fluid (CSF) in platelet-dependent hemostasis during neurosurgery.METHODS: The amplification of aggregation, activation of integrin αIIbβ3, intrinsic and extrinsic coagulation pathways, and activation of signaling cascades in platelets were evaluated. Read More