Thombal RS1, Jadhav VH.
Org Biomol Chem. 2015 Sep 28;13(36):9485-91. doi: 10.1039/c5ob01276g. Epub 2015 Aug 10.The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.