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Home > Product > Heterocyclic Organic Compounds > 3-Amino-4-methylphenylboronic acid hydrochloride

3-Amino-4-methylphenylboronic acid hydrochloride | CAS Number: 22237-12-3

Catalog Number
ACM22237123
Product Name
3-Amino-4-methylphenylboronic acid hydrochloride
Structure
CAS Number
22237-12-3
Synonyms
3-AMINO-4-METHYLPHENYLBORONIC ACID;(3-AMINO-4-METHYLPHENYL)BORONIC ACID, HCL;3-AMINO-4-METHYLPHENYLBORONIC ACID HYDROCHLORIDE;3-AMINO-4-METHYLBENZENEBORONIC ACID;3-Amino-4-methylphenylboronic acid~3-Amino-p-tolylboronic acid;3-AMINO-4-METHYLPHENYLBORONIC
Molecular Weight
150.97
Molecular Formula
C7H10BNO2
Purity
98%
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1Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

Chappell MD, Li R, Smith SC, Dressman BA, Tromiczak EG, Tripp AE, Blanco MJ, Vetman T, Quimby SJ, Matt J, Britton TC, Fivush AM, Schkeryantz JM, Mayhugh D, Erickson JA, Bures MG, Jaramillo C1, Carpintero M1, Diego JE1, Barberis M1, Garcia-Cerrada S1, Sori

J Med Chem. 2016 Dec 22;59(24):10974-10993. Epub 2016 Dec 6.

As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid scaffold to generate mGlu2/3 antagonists. Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3. Read More

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Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA