Wang Y1, Wang H, Lv X, Liu C, Qi L, Song X, Yu A.
Macromol Biosci. 2014 Mar;14(3):369-79. doi: 10.1002/mabi.201300295. Epub 2013 Sep 23.Cancer differentiation therapy is an attractive concept and has been clinically used to treat leukemia. However, it is limited to date for solid tumors. In this study, the pH-sensitive nanoparticles based on poly(amidoamine) (PAMAM) dendrimers are synthesized by coupling 3,4,5,6-tetrahydrophthalic anhydride with the first generation PAMAM. The modified dendrimers can self-assemble in aqueous solution to form nanoparticles with a diameter of 125-435 nm. Read More