Chinisaz M1, Ebrahim-Habibi A2, Dehpour AR3, Yaghmaei P4, Parivar K4, Moosavi-Movahedi AA5.
Eur J Pharm Sci. 2017 Jan 1;96:342-350. doi: 10.1016/j.ejps.2016.09.030. Epub 2016 Sep 27.Insulin is a therapeutic protein whose amyloid formation is reported in diabetic patients. Four anhydride compounds were used in the current study in order to experiment their potential reducing effect on insulin propensity to form amyloid fibrils. The modified forms (obtained with succinic-, 3,3-dimethylglutaric, 2-phenylglutaric-, and (2-Dodecen-1-yl) succinic anhydride), were first characterized with regard to melting temperature (Tm), changes in secondary structure percentage and hydrophobic surface. Read More