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Home > Product > Heterocyclic Organic Compounds > 2-Methylpyridine-4-boronic acid pinacol ester

2-Methylpyridine-4-boronic acid pinacol ester | CAS Number: 660867-80-1

Catalog Number
ACM660867801
Product Name
2-Methylpyridine-4-boronic acid pinacol ester
Structure
CAS Number
660867-80-1
IUPAC Name
2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Synonyms
2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER;2-METHYL-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE;2-Picoline-4-boronic acid pinacol ester;2-Picoline-4-boronic acid pinacolate;2-Methyl-4-pyridineboronic acid pinacol ester;2-Methylpyridine-4-
Molecular Weight
219.09
Exact Mass
219.14300
Molecular Formula
C12H18BNO2
Boiling Point
315.9ºC at 760 mmHg
Melting Point
66-71ºC
Flash Point
144.8ºC
Density
1.02g/cm3
Purity
95%
Appearance
yellow powder
InChIKey
MBTULFIFECUURA-UHFFFAOYSA-N
H-Bond Donor
0
H-Bond Acceptor
3
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1Synthesis of C-4 Substituted Amido Nicotine Derivatives via Copper(I)- and (II)-Catalyzed Cross-Coupling Reactions.

Zhu J1, Enamorado MF1, Comins DL1.

J Org Chem. 2016 Nov 18;81(22):11529-11534. Epub 2016 Nov 1.

The syntheses of seven novel amido nicotine derivatives 12-18 from (S)-nicotine are presented. (S)-Nicotine and (S)-6-chloronicotine derivatives were cross-coupled with the corresponding amides 6-10 at the C-4 position of the pyridine ring via copper(I)-mediated reactions. Derivatives 16-18 were also obtained via copper(II)-mediated reactions from (S)-nicotine containing a C-4 boronic acid pinacol ester group. The optimization of reaction conditions for both routes provided a useful method for preparing C-4 amide-containing nicotine analogs.

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Tel:1-201-478-8534
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Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA