Kostova B1, Ivanova S, Balashev K, Rachev D, Christova D.
AAPS PharmSciTech. 2014 Aug;15(4):939-46. doi: 10.1208/s12249-014-0120-0. Epub 2014 May 3.Segmented copolymer networks (SCN) based on poly(2-ethyl-2-oxazoline) and containing 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, and/or methyl methacrylate segments have been evaluated as potential sustained release systems of the water soluble cardioselective β-blocker metoprolol tartrate. The structure and properties of the drug carriers were investigated by differential scanning calorimetry, attenuated total reflectance Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy. Read More