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Home > Product > Heterocyclic Organic Compounds > 2-Chloro-4-methylphenylboronic acid pinacol ester

2-Chloro-4-methylphenylboronic acid pinacol ester | CAS Number: 145349-62-8

Catalog Number
ACM145349628
Product Name
2-Chloro-4-methylphenylboronic acid pinacol ester
Structure
CAS Number
145349-62-8
Synonyms
2-CHLORO-4-METHYLPHENYLBORONIC ACID;2-CHLORO-4-METHYLPHENYLBORONIC ACID PINACOL ESTER;2-CHLORO-4-METHYLBENZENEBORONIC ACID, PINACOL ESTER;AKOS BRN-0715;2-Chloro-4-methylbenzeneboronic acid;2-Chloro-4-Methylphenylboronic;2-Chloro-p-tolylboronic acid;4-Boro
Molecular Weight
170.4
Molecular Formula
C7H8BClO2
Purity
98%
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1Synthesis of C-4 Substituted Amido Nicotine Derivatives via Copper(I)- and (II)-Catalyzed Cross-Coupling Reactions.

Zhu J1, Enamorado MF1, Comins DL1.

J Org Chem. 2016 Nov 18;81(22):11529-11534. Epub 2016 Nov 1.

The syntheses of seven novel amido nicotine derivatives 12-18 from (S)-nicotine are presented. (S)-Nicotine and (S)-6-chloronicotine derivatives were cross-coupled with the corresponding amides 6-10 at the C-4 position of the pyridine ring via copper(I)-mediated reactions. Derivatives 16-18 were also obtained via copper(II)-mediated reactions from (S)-nicotine containing a C-4 boronic acid pinacol ester group. The optimization of reaction conditions for both routes provided a useful method for preparing C-4 amide-containing nicotine analogs.

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