Deng Y1, Zhang Y, Jiang H, Xu L, Liu H, Li S, He N.
J Biomed Nanotechnol. 2009 Oct;5(5):551-6.Various alkyl-phenylboronic acids have been widely used in the fields of electronics, chemistry, medicine and biology, especially in glucose sensors and intermediates of medicines. In this paper, the syntheses of two or three different alkyl-phenylboronic acids and the improvement on synthesis processes were studied with Grignard reagent method in detail. The influencing factors such as temperature, reaction time, reactant molar ratio were analyzed with the orthogonal experiment; optimized processes for the preparation of different alkyl-phenylboronic acids were thus obtained using different alkylborates as original materials. Read More