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Home > Product > Heterocyclic Organic Compounds > 2,6-Difluoropyridine-3-boronic acid

2,6-Difluoropyridine-3-boronic acid | CAS Number: 136466-94-9

Catalog Number
ACM136466949
Product Name
2,6-Difluoropyridine-3-boronic acid
Structure
CAS Number
136466-94-9
IUPAC Name
(2,6-difluoropyridin-3-yl)boronic acid
Synonyms
(2,6-DIFLUORO-3-PYRIDINYL)-BORONIC ACID;2,6-DIFLUORO-3-PYRIDYL BORONIC ACID;(2,6-DIFLUOROPYRIDIN-3-YL)BORONIC ACID;2,6-DIFLUOROPYRIDINE-3-BORONIC ACID;Boronic acid, (2,6-difluoro-3-pyridinyl)- (9CI);6-Chloro-2-fluoropyridine-3-boronic acid;REF DUPL: 2,6-D
Molecular Weight
158.9
Exact Mass
159.03000
Molecular Formula
C5H4BF2NO2
Boiling Point
314.8ºC at 760 mmHg
Flash Point
144.2ºC
Density
1.44 g/cm3
Purity
96%
Appearance
White powder
SMILES
B(C1=C(N=C(C=C1)F)F)(O)O
InChIKey
LCCZTROJRJFXNV-UHFFFAOYSA-N
H-Bond Donor
2
H-Bond Acceptor
5
Hazard Statements
Xi
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1Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis.

Lyberg K1,2, Ali HA3,2, Grootens J1,2, Kjellander M3, Tirfing M1, Arock M4, Hägglund H5, Nilsson G1,2, Ungerstedt J3,2.

Oncotarget. 2016 Dec 25. doi: 10.18632/oncotarget.14181. [Epub ahead of print]

Systemic mastocytosis (SM) is a clonal bone marrow disorder, where therapeutical options are limited. Over 90% of the patients carry the D816V point mutation in the KIT receptor that renders this receptor constitutively active. We assessed the sensitivity of primary mast cells (MC) and mast cell lines HMC1.2 (D816V mutated), ROSA (KIT WT) and ROSA (KIT D816V) cells to histone deacetylase inhibitor (HDACi) treatment. Read More

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Tel:1-201-478-8534
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