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Home > Product > Heterocyclic Organic Compounds > 2,6-Difluoro-3-ethoxybenzeneboronic acid

2,6-Difluoro-3-ethoxybenzeneboronic acid | CAS Number: 849062-00-6

Catalog Number
ACM849062006
Product Name
2,6-Difluoro-3-ethoxybenzeneboronic acid
Structure
CAS Number
849062-00-6
IUPAC Name
(3-ethoxy-2,6-difluorophenyl)boronic acid
Synonyms
2,6-Difluoro-3-ethoxybenzeneboronic acid;2,6-Difluoro-3-ethoxybenzeneboronic acid 98%;2,6-Difluoro-3-ethoxybenzeneboronicacid98%;3-Ethoxy-2,6-difluorophenylboronic acid
Molecular Weight
201.9630664
Exact Mass
202.06100
Molecular Formula
C8H9BF2O3
Boiling Point
341.6ºC at 760 mmHg
Melting Point
76-77ºC
Flash Point
160.4ºC
Density
1.29 g/cm3
Purity
98%
SMILES
B(C1=C(C=CC(=C1F)OCC)F)(O)O
InChIKey
XNCPAOSJJNRPHW-UHFFFAOYSA-N
H-Bond Donor
2
H-Bond Acceptor
5
Safty Description
26-36/37/39-45
Hazard Statements
Xi: Irritant;C: Corrosive;
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1Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis.

Lyberg K1,2, Ali HA3,2, Grootens J1,2, Kjellander M3, Tirfing M1, Arock M4, Hägglund H5, Nilsson G1,2, Ungerstedt J3,2.

Oncotarget. 2016 Dec 25. doi: 10.18632/oncotarget.14181. [Epub ahead of print]

Systemic mastocytosis (SM) is a clonal bone marrow disorder, where therapeutical options are limited. Over 90% of the patients carry the D816V point mutation in the KIT receptor that renders this receptor constitutively active. We assessed the sensitivity of primary mast cells (MC) and mast cell lines HMC1.2 (D816V mutated), ROSA (KIT WT) and ROSA (KIT D816V) cells to histone deacetylase inhibitor (HDACi) treatment. Read More

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Tel:1-201-478-8534
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Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA