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Home > Product > Heterocyclic Organic Compounds > 2,5-Dimethoxyphenylboronic acid

2,5-Dimethoxyphenylboronic acid | CAS Number: 107099-99-0

Catalog Number
ACM107099990
Product Name
2,5-Dimethoxyphenylboronic acid
Structure
CAS Number
107099-99-0
Synonyms
AKOS BRN-0036;2,5-DIMETHOXYPHENYLBORONIC ACID;2,5-DIMETHOXYBENZENEBORONIC ACID;CHEMBRDG-BB 3200971;RARECHEM AH PB 0098;2,5-Dimethoxyphenylboronic;2,5-DIMETHOXYPHENYLBORONIC ACID,99+%;2,5-Dimethoxyphenylboronic Acid (contains varying amounts of Anhydride)
Molecular Weight
181.98
Molecular Formula
C8H11BO4
Purity
98%
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1Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis.

Lyberg K1,2, Ali HA3,2, Grootens J1,2, Kjellander M3, Tirfing M1, Arock M4, Hägglund H5, Nilsson G1,2, Ungerstedt J3,2.

Oncotarget. 2016 Dec 25. doi: 10.18632/oncotarget.14181. [Epub ahead of print]

Systemic mastocytosis (SM) is a clonal bone marrow disorder, where therapeutical options are limited. Over 90% of the patients carry the D816V point mutation in the KIT receptor that renders this receptor constitutively active. We assessed the sensitivity of primary mast cells (MC) and mast cell lines HMC1.2 (D816V mutated), ROSA (KIT WT) and ROSA (KIT D816V) cells to histone deacetylase inhibitor (HDACi) treatment. Read More

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