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Home > Product > Heterocyclic Organic Compounds > 2,4-Dimethoxyprimidine-5-boronic acid

2,4-Dimethoxyprimidine-5-boronic acid | CAS Number: 89641-18-9

Catalog Number
ACM89641189
Product Name
2,4-Dimethoxyprimidine-5-boronic acid
Structure
CAS Number
89641-18-9
Synonyms
RARECHEM AH PB 0101;AKOS BRN-0112;2,4-Dimethoxyprimidine-5-boronic acid ;2,4-Dimethoxy-pyrimidine-5-boric acid;2,4-Dimethoxy-5-Pyrimidine boronic acid;2,4-DIMETHOXYPRYIMIDINE-5-BORONIC ACID;2,4-Dimethoxypyrimidine-5-Boro;(2,4-DIMETHOXYPYRIMIDIN-5-YL)BORON
Molecular Weight
183.96
Molecular Formula
C6H9BN2O4
Purity
98%
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1Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis.

Lyberg K1,2, Ali HA3,2, Grootens J1,2, Kjellander M3, Tirfing M1, Arock M4, Hägglund H5, Nilsson G1,2, Ungerstedt J3,2.

Oncotarget. 2016 Dec 25. doi: 10.18632/oncotarget.14181. [Epub ahead of print]

Systemic mastocytosis (SM) is a clonal bone marrow disorder, where therapeutical options are limited. Over 90% of the patients carry the D816V point mutation in the KIT receptor that renders this receptor constitutively active. We assessed the sensitivity of primary mast cells (MC) and mast cell lines HMC1.2 (D816V mutated), ROSA (KIT WT) and ROSA (KIT D816V) cells to histone deacetylase inhibitor (HDACi) treatment. Read More

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