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Home > Product > Heterocyclic Organic Compounds > 2,3-Dichloro-4-pyridineboronic acid

2,3-Dichloro-4-pyridineboronic acid | CAS Number: 951677-39-7

Catalog Number
ACM951677397
Product Name
2,3-Dichloro-4-pyridineboronic acid
Structure
CAS Number
951677-39-7
IUPAC Name
(2,3-dichloropyridin-4-yl)boronic acid
Synonyms
2,3-Dichloropyridine-4-boronic acid;2,3-Dichloro-4-pyridineboronic acid;4-Borono-2,3-dichloropyridine
Molecular Weight
191.81
Exact Mass
190.97100
Molecular Formula
C5H4BCl2NO2
Boiling Point
375.7ºC at 760 mmHg
Melting Point
136-138ºC
Flash Point
181ºC
Density
1.56g/cm3
Purity
95%
InChIKey
ABRTZUPJNVJMHP-UHFFFAOYSA-N
H-Bond Donor
2
H-Bond Acceptor
3
Hazard Statements
Xi
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1Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis.

Lyberg K1,2, Ali HA3,2, Grootens J1,2, Kjellander M3, Tirfing M1, Arock M4, Hägglund H5, Nilsson G1,2, Ungerstedt J3,2.

Oncotarget. 2016 Dec 25. doi: 10.18632/oncotarget.14181. [Epub ahead of print]

Systemic mastocytosis (SM) is a clonal bone marrow disorder, where therapeutical options are limited. Over 90% of the patients carry the D816V point mutation in the KIT receptor that renders this receptor constitutively active. We assessed the sensitivity of primary mast cells (MC) and mast cell lines HMC1.2 (D816V mutated), ROSA (KIT WT) and ROSA (KIT D816V) cells to histone deacetylase inhibitor (HDACi) treatment. Read More

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