Wang FX1, Chen MH1, Hu XY1, Ye RR1, Tan CP1, Ji LN1, Mao ZW1.
Sci Rep. 2016 Dec 13;6:38954. doi: 10.1038/srep38954.Organometallic iridium complexes are potent anticancer candidates which act through different mechanisms from cisplatin-based chemotherapy regimens. Here, ten phosphorescent cyclometalated iridium(III) complexes containing 2,2'-bipyridine-4,4'-dicarboxylic acid and its diester derivatives as ligands are designed and synthesized. The modification by ester group, which can be hydrolysed by esterase, facilitates the adjustment of drug-like properties. Read More