Ghinet A1, Moise IM2, Rigo B3, Homerin G3, Farce A4, Dubois J5, Bîcu E6.
Bioorg Med Chem. 2016 May 15;24(10):2307-17. doi: 10.1016/j.bmc.2016.04.001. Epub 2016 Apr 1.New phenothiazine derivatives 6-20 have been designed, synthesized and evaluated in vitro for their ability to inhibit tubulin polymerization and antiproliferative activity against 60 cancer cell lines, including several multi-drug resistant (MDR) tumor cell lines. The phenothiazine unit may successfully replace the classical 3,4,5-trimethoxyphenyle A ring of parent combretastatin A-4 or phenstatin, confirming previous studies. Read More