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10-Methylphenothiazine | CAS Number: 1207-72-3

Catalog Number
ACM1207723
Product Name
10-Methylphenothiazine
Structure
CAS Number
1207-72-3
EC Number
214-896-8
IUPAC Name
10-methylphenothiazine
Synonyms
N-METHYLPHENOTHIAZINE;10-methyl-10h-phenothiazin;10-Methyl-10H-phenothiazine;9,10-Dibenzoisothiazine, 10-methyl-;Phenothiazide methyl derivative;Phenothiazine, 10-methyl-;AKOS 93806;10-METHYLPHENOTHIAZINE
Molecular Weight
213.3
Exact Mass
213.06100
Molecular Formula
C13H11NS
Boiling Point
341.6ºC at 760mmHg
Melting Point
99 - 101ºC
Flash Point
160.4ºC
Density
1.207g/cm3
Purity
96%
Appearance
off-white crystals
SMILES
CN1C2=CC=CC=C2SC3=CC=CC=C31
InChIKey
QXBUYALKJGBACG-UHFFFAOYSA-N
H-Bond Donor
0
H-Bond Acceptor
1
Safty Description
26-36
Hazard Statements
Xi
WGK Germany
3
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1Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents.

Ghinet A1, Moise IM2, Rigo B3, Homerin G3, Farce A4, Dubois J5, Bîcu E6.

Bioorg Med Chem. 2016 May 15;24(10):2307-17. doi: 10.1016/j.bmc.2016.04.001. Epub 2016 Apr 1.

New phenothiazine derivatives 6-20 have been designed, synthesized and evaluated in vitro for their ability to inhibit tubulin polymerization and antiproliferative activity against 60 cancer cell lines, including several multi-drug resistant (MDR) tumor cell lines. The phenothiazine unit may successfully replace the classical 3,4,5-trimethoxyphenyle A ring of parent combretastatin A-4 or phenstatin, confirming previous studies. Read More

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Email:
Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA