Jackson AW1, Chandrasekharan P2, Ramasamy B2, Goggi J2,3, Chuang KH2,3,4, He T1, Robins EG2,4.
Biomacromolecules. 2016 Dec 12;17(12):3902-3910. Epub 2016 Dec 1.Reversible addition-fragmentation chain transfer (RAFT) polymerization has been employed to synthesize branched block copolymer nanoparticles possessing 1,4,7,10-tetraazacyclododecane-N,N,'N,″N,‴-tetraacetic acid (DO3A) macrocycles within their cores and octreotide (somatostatin mimic) cyclic peptides at their periphery. These polymeric nanoparticles have been chelated with Gd3+ and applied as magnetic resonance imaging (MRI) nanocontrast agents. Read More