Páv O1, Barvík I2, Liboska R1, Petrová M1, Šimák O3, Rosenbergová Š1, Novák P1, Buděšínský M1, Rosenberg I1.
Org Biomol Chem. 2016 Dec 20. [Epub ahead of print]The concept of conformational restriction leading to the preorganization of modified strands has proven to be successful and has afforded nucleic acid analogues with many interesting properties suitable for various biochemical applications. We utilized this concept to prepare a set of constrained oligonucleotides derived from 1,4-dioxane and 1,3-dioxolane-locked nucleoside phosphonates and evaluated their hybridization affinities towards their complementary RNA strands. Read More