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1,3-Dioxolane | CAS Number: 646-06-0

Catalog Number
ACM646060
Product Name
1,3-Dioxolane
Structure
CAS Number
646-06-0
Synonyms
1,3-Dioxolan;1,3-Dioxole, dihydro-;1,3-dioxole,dihydro-;1,3-dixolane;dihydro-1,3-dioxole;dihydro-3-dioxole;Dioxolan;dioxolane(non-specificname)
Molecular Weight
74.08
Molecular Formula
C3H6O2
Purity
>98.0%(GC)
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1Tuning the hybridization properties of modified oligonucleotides: from flexible to conformationally constrained phosphonate internucleotide linkages.

Páv O1, Barvík I2, Liboska R1, Petrová M1, Šimák O3, Rosenbergová Š1, Novák P1, Buděšínský M1, Rosenberg I1.

Org Biomol Chem. 2016 Dec 20. [Epub ahead of print]

The concept of conformational restriction leading to the preorganization of modified strands has proven to be successful and has afforded nucleic acid analogues with many interesting properties suitable for various biochemical applications. We utilized this concept to prepare a set of constrained oligonucleotides derived from 1,4-dioxane and 1,3-dioxolane-locked nucleoside phosphonates and evaluated their hybridization affinities towards their complementary RNA strands. Read More

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Email:
Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: Suite 212, Waverly Plaza, 755 Waverly Avenue, Holtsville, NY 11742, USA